4-Fmoc-morpholine-2-carboxylic acid
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid
CAS: 312965-04-1
Molecular Formula: C20H19NO5
4-Fmoc-morpholine-2-carboxylic acid - Names and Identifiers
| Name | 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid |
| Synonyms | Fmoc-Cop FMOC-COP RARECHEM EM WB 0088 2-carboxy-4-Fmoc-morpholine (R,S)-FMOC-2-CARBOXYMORPHOLINE 4-FMoc-2-Morpholinecarboxylic acid 4-Fmoc-morpholine-2-carboxylic acid 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid 2,4-morpholinedicarboxylic acid, 4-(9H-fluoren-9-ylmethyl) ester 2,4-Morpholinedicarboxylic acid, 4-(9H-fluoren-9-ylmethyl) ester |
| CAS | 312965-04-1 |
| InChI | InChI=1/C20H19NO5/c22-19(23)18-11-21(9-10-25-18)20(24)26-12-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17-18H,9-12H2,(H,22,23) |
4-Fmoc-morpholine-2-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C20H19NO5 |
| Molar Mass | 353.37 |
| Density | 1.344g/cm3 |
| Melting Point | 87-89°C |
| Boling Point | 579.8°C at 760 mmHg |
| Flash Point | 304.4°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.77E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Store at 0°C |
| Refractive Index | 1.621 |
4-Fmoc-morpholine-2-carboxylic acid - Introduction
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is an organic compound with the chemical formula C21H19NO5. It is a white to pale yellow crystalline solid.
Nature:
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is a carboxylic acid compound derived from morpholine, and an Fmoc protecting group is used to protect the carboxyl function. It is soluble in organic solvents and has stable chemical properties.
Use:
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is mainly used for peptide synthesis in organic synthesis, in which Fmoc protecting group can be used to prevent the reaction of carboxyl group. The compound is also used in pharmaceutical research and other related applications in ligand design and synthetic chemistry.
Method:
The preparation of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is generally obtained by reacting 2-morpholinecarboxylic acid with Fmoc-OSu (sulfoxyphthalimide) under basic conditions. Hydrolysis with sodium hydroxide or potassium hydroxide solution gives 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid.
Safety Information:
Regarding the safety information of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid, there is no clear toxicity and danger data in the relevant literature. However, as an organic compound, it needs to follow the correct experimental practice when used, and take appropriate protective measures, such as wearing gloves, goggles and laboratory coats. It is best to operate in a well-ventilated area and away from open flames and heat sources. If necessary, it is recommended to use the compound under the guidance of a professional.
Nature:
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is a carboxylic acid compound derived from morpholine, and an Fmoc protecting group is used to protect the carboxyl function. It is soluble in organic solvents and has stable chemical properties.
Use:
4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is mainly used for peptide synthesis in organic synthesis, in which Fmoc protecting group can be used to prevent the reaction of carboxyl group. The compound is also used in pharmaceutical research and other related applications in ligand design and synthetic chemistry.
Method:
The preparation of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid is generally obtained by reacting 2-morpholinecarboxylic acid with Fmoc-OSu (sulfoxyphthalimide) under basic conditions. Hydrolysis with sodium hydroxide or potassium hydroxide solution gives 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid.
Safety Information:
Regarding the safety information of 4-[(9H-fluoren-9-ylmethoxy)carbonyl]morpholine-2-carboxylic acid, there is no clear toxicity and danger data in the relevant literature. However, as an organic compound, it needs to follow the correct experimental practice when used, and take appropriate protective measures, such as wearing gloves, goggles and laboratory coats. It is best to operate in a well-ventilated area and away from open flames and heat sources. If necessary, it is recommended to use the compound under the guidance of a professional.
Last Update：2024-04-09 21:32:40
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CAS: 312965-04-1
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CAS: 312965-04-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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